Preventing recurrent pregnancy loss: time to rethink the standard of care?

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Molecular Mechanisms of Recurrent Pregnancy Loss

Introduction: Pregnancy and health is the process in which the egg is fertilized and being able to survive. When pregnancy occurs under some conditions and the fetus is being at risk, it will lead to abortion that occurs involuntarily and spontaneously. Abortions that occur more than two or three times are called recurrent pregnancy loss (RPL). Various etiological factors involved in RPL, inclu...

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I-32: Predictive Factors of Recurrent Pregnancy Loss

Background Accurate prevalence figures are not available, but it has been estimated that 1-2% of women have recurrent pregnancy loss (RPL), defined as three or more consecutive losses of intrauterine pregnancy in the first trimester. Half of whom have no identifiable cause. Recent studies of early pregnancy loss, preeclampsia, pregnancy complications such a hydatidiform mole suggests that these...

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The Effect of Lymphocyte Therapy on the Expression of MicroRNAs in Women with Recurrent Pregnancy Loss

Background: Recurrent Pregnancy Loss (RPL) is 2 or more recurrent miscarriages before the twentieth week, which occurs in 2-5% of women of gestational age. Considering the significant role of the immune system in the process of a successful pregnancy, it is expected that in addition to the common and well-known treatments used for patients with recurrent miscarriage to date, intracutaneous lymp...

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The Effect of HLA-DRB1 Sharing between the Couples with Recurrent Pregnancy Loss on the Pregnancy Outcome after Leukocyte Therapy

Background: Miscarriage is a common phenomenon complicating more than half of pregnancies. Recurrent Pregnancy Loss (RPL) is defined as three or more pregnancies lost before the twentieth week of gestation. It is believed that abnormality in maternal immune reaction to fetus and sharing of HLA antigens might be associated with RPL. Objective: To investigate the effect of HLA-DRB1 sharing betwee...

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Recurrent pregnancy loss

Recurrent pregnancy loss (RPL) refers to the consecutive loss of three or more clinically recognized pregnancies prior to the 20th week of gestation (excluding ectopic, molar and biochemical pregnancies). RPL is classified into two categories: primary RPL, which consists of repeated miscarriages in which a pregnancy has never been carried to viability; and secondary RPL, in which a live birth h...

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ژورنال

عنوان ژورنال: Nature Reviews Rheumatology

سال: 2009

ISSN: 1759-4790,1759-4804

DOI: 10.1038/nrrheum.2009.66